Screening for cystic fibrosis by measurement of unstimulated parotid saliva sodium levels.
نویسندگان
چکیده
منابع مشابه
Screening for cystic fibrosis by measurement of unstimulated parotid saliva sodium levels.
The prognosis of cystic fibrosis depends very largely upon the earliest possible diagnosis, and the institution of a careful regime of management, including physiotherapy, pancreatin replacement, and antibiotics, before lung damage has been caused by respiratory obstruction and infection. The ideal method of doing this would be by a screening test in early infancy which could be applied to the ...
متن کاملPilot trial of an infant screening programme for cystic fibrosis: measurement of parotid salivary sodium at 4 months.
Cystic fibrosis (CF), transmitted by a single autosomal recessive gene, affects 1 in 2500 of the population. A biochemical abnormality affects the quality of mucus, and results in pancreatic duct obstruction, and progressive lung damage as a result of respiratory infection. Thirty years ago it is probable that almost all affected babies died of pneumonia in the first two years of life. Over the...
متن کاملScreening for cystic fibrosis.
Neonatal screening for cystic fibrosis (CF) reduces short-term morbidity but its long term effects remain to be demonstrated. The best available method is the assay of immunoreactive trypsin in dried blood spots, and specificity can be improved by adding direct or indirect genetic analysis. Pregnancies known to be at risk of CF can also be screened by molecular methods, and affected pregnancies...
متن کاملScreening for cystic fibrosis.
Sir, In their Short Report on screening for cystic fibrosis, Vol. 47, pages 131-134, Drs. Cain, Deall, and Noble expressed the hope that their trial would stimulate other maternity units to carry out similar surveys so that the efficiency of the method could be more rapidly assessed. In 1969 we started developing an immunochemical method to analyse meconium for albumin, and since August 1971 we...
متن کاملScreening for cystic fibrosis.
During a 12 month period all New Zealand newborns were screened for cystic fibrosis using the Crossley test. Of 49 056 babies tested 522 had a raised blood immunoreactive trypsin level and follow-up testing indicated 19 persistent elevations. Clinical and laboratory studies indicated 14 cases of cystic fibrosis giving an apparent incidence of 1:3500.
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ژورنال
عنوان ژورنال: Archives of Disease in Childhood
سال: 1967
ISSN: 0003-9888,1468-2044
DOI: 10.1136/adc.42.226.689